I am doing revision due to rejection currently.
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INSULIN RESISTANCE HAS STRONG ASSOCIATED WITH OBESITY MECHANISM
Increased FFAs can cause oxidative stress and
activation of JNK pathway. JNK pathway is believed to be strongly associated
with obesity involved in impairment of insulin signalling. Thus, it leads to
insulin resistance in cells and tissue that are dependent on insulin.
Activation of JNK pathway leads to increasing phosphorylation of serine residue
IRS-1 which no longer functions towards to PI3K protein. The inhibition of
PI3K, reduce the expression of Akt protein which inactivate GLUT4 to take up
glucose into the cells. This causes the elevation of glucose in the bloodstream
and hyperinsulinemia outside the cell membrane (Adapted from Shoelson et al., 2006 and Go, Uysal, & Maeda, 2002).
References:
1-Go, C. Z., Uysal, K. T., & Maeda, K. (2002). A central
role for JNK in obesity and insulin resistance, 2, 10–13.
2-Shoelson, S. E., Lee, J., & Goldfine, A. B. (2006).
Review series Inflammation and insulin resistance. The Journal of Clinical
Investigation, 116(7), 1793–1801.
http://doi.org/10.1172/JCI29069.and
MEDLAB CONFERENCE
The conference was held in 2016 at Marina Bay, Singapore. It was great opportunity to meet a lot of people who are doing in the same field like me.
Ceramides are the metabolite that modulating diabetes event in the blood. Previous study found that it can give effects to the insulin signalling by inducing free fatty acids towards the cells.
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